Vitamin B1 is also known as thiamine. It is found naturally in plants, mushrooms and other fungi, and bacteria and is responsible for proper functioning of the heart and nervous system. Too little vitamin B1, caused by malnutrition or eating foods containing too much of the enzyme that breaks this vitamin down can result in serious side effects. Vitamin B1 deficiency can cause beriberi, a neurological disease that makes it harder to use the muscles and limps. In severe cases, a lack of vitamin B1 can lead to heart failure. Doctors may order a vitamin B1 blood test in patients with motor problems, muscular atrophy, heart trouble or unexpected weight loss.